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Usbio/215175-ML650 Rat Anti-TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 650)/215175-ML650/100ul
Usbio/215175-ML650 Rat Anti-TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (MaxLight 650)/215175-ML650/100ul
商品编号：
215175-ML650
品牌：
USbiological
市场价：
¥13320.00
美元价：
5661.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000.
Tim-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily, is exclusively expressed by antigen-presenting cells, which acts as the natural ligand of Tim-1, involved in T-cell expansion and cytokine production. Tim-4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on DCs, enhances Th2 cell function. The TIM-4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma. Studies have shown that Tim-4 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1+ cells), but not PEMs (peritoneal exudate Mac1+ cells) see Nakayama, M. et al. . for details.
Applications: |Suitable for use in Immunofluorescence, Flow Cytometry and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry: paraffin sectionsOptimal dilutions to be determined by the researcher.
Hybridoma: |Lymph node cells from immunized SD rats were fused with cells of the P3U1 myeloma cell line.
Positive Control
Mouse spleen
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight™650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
Tim-4-Ig, consisting of aa1-288 from mouse Tim-4, coupled with the Fc portion of mouse IgG2a.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™650.
Purity
Purified by Protein G affinity chromatographyfrom tissue culture supernatant.
Specificity
Recognizes mouse TIM-4.
References
1. Nakayama, M. et al. (2009) Tim3 mediates phagocytosis of apoptotic cells and crosspresentation. Blood. 113: 38213830. 2. Freeman, G.J. et al. (2011) TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol. Rev. 235: 172189.品牌介绍
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