ThesirtuinsrepresentadistinctclassoftrichostatinA-insensitivelysyl-deacetylases(classIIIHDACs)andhavebeenshowntocatalyzeareactionthatcoupleslysinedeacetylationtotheformationofnicotinamideandO-acetyl-ADP-ribosefromNAD+andtheabstractedacetylgroup.Therearesevenhumansirtuins,whichhavebeendesignatedSIRT1-7.SIRT5islocatedinthemitochondrialmatrixanditsfunctionsarelargelystillbeingelucidated,howeverafewpromisingsubstrateshavebeenstudied.SIRT5hasbeenshowntodeacetylatecarbamoylphosphatesynthetase1(CSP1),activatingtheenzymetocatalyzethefirststepoftheureacycle.CSP1isimportantinthedetoxificationofexcessammoniathatcanaccumulateduringfasting.CytochromeC,anothermitochondrialenzymeinvolvedinoxidativemetabolismcanalsobedeacetylatedbySIRT5.SIRT5ispredominantlyfoundintheheart,brain,testis,andlymphoblasts.||Source:|RecombinantproteincorrespondingtohumanSIRT5,fusedtoGST-tagatN-terminal,expressedinE.coli.||MolecularWeight:|~60.6kD(NTGST-tag),~26kD(native)||StorageandStABIlity:|Aliquottoavoidrepeatedfreezingandthawingandstoreat-70°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Source:E.coli|Purity:~90%(SDS-PAGE)|Concentration:Asreported|Form:Suppliedasaliquidin50mMsodiumphosphate,pH7.2,100mMsodiumchloride,20%glycerol.||ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplicationswithouttheexpressedwrittenauthorizationofUnitedStatesBIOLOGical.

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