Thisgeneencodesamemberofasuperfamilyofproteinscomposedpredominantlyoftandemlyarrayedshortconsensusrepeatsofapproximately60aa.Asingle,uniquebeta-chainencodedbythisgeneassembleswithsevenidenticalalpha-chainsintothepredominantisoformofC4b-bindingprotein,amultimericproteinthatcontrolsactivationofthecomplementcascadethroughtheclassicalpathway.C4b-bindingproteinhasaregulatoryroleinthecoagulationsystemalso,mediatedthroughthebeta-chainbindingofproteinS,avitaminK-dependentproteinthatservesasacofactorofactivatedproteinC.Thegenesencodingbothalphaandbetachainsarelocatedadjacenttoeachotheronhumanchromosome1intheregulatorofcomplementactivationgenecluster.Alternativesplicinggivesrisetomultipletranscriptvariants.||Applications:|SuitableforuseinELISA,WesternBlot.Otherapplicationsnottested.||RecommendedDilution:|WesternBlot:1:500–1:2000|Immunohistochemistry:1:50–1:100|Immunofluorescence:1:50–1:100|Optimaldilutionstobedeterminedbytheresearcher.||StorageandStABIlity:|Maybestoredat4°Cforshort-termonly.Aliquottoavoidrepeatedfreezingandthawing.Storeat-20°C.Aliquotsarestablefor12monthsafterreceipt.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.

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