Carboxylesterase 2 is a member of a serine esterase f amily composed of enzymes which hydrolyze ester and amide bonds. The member s in t his family share the serine hydrolase fold observed in other esterases . They have broad substrate specificity from small moleculeesters such as phenylesterto long­chain fatty acidest ers and thioesters. They play a major role in the pharmacokinetics of most therapeutic agents containing anester. By de­esterification, they can activate or inactivate the agents. They also participate in the detoxification of drugs such as cocaine and heroin in serum and liver. In addition to narcotics, they can also detoxify or ganophosphate and carbamate analogues used in agrochemicals or chemical nerve agents, such as malathion, sarin, tabun, and VX. In addition to the hydrolyticactivity, they can perform transesterification. This reaction is important for cholesterol homeostasis. Three major human CESs have been identified. CES-1 is highly expressed in liver. CES­2 is present in the small intestine, colon, kidney, liver, heart , brain, and testis. CES ­3 is brain­specific. Carboxylesterase deficiency may be associated with non­Hodgkin lymphoma or B­cell l ymphocytic leukemia.||SDS-PAGE: |63kD under reducing conditions||Activity: |Measured by its ability to hydrolyze p-nitrophenylacetate. The specific activity is >30,000pmol/min/ug.||Storage and Stability:|Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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