Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.||Melting Point:|199-203ºC||Solubility:|DMSO||Method for Determining Identity:|Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis||TLC Conditions:|SiO2: Dichloromethane: Methanol = 9.5: 0.5; Visualized with UV and AMCS; SIngle spot, Rf=0.6||Atmosphere: Inert gas||Storage and Stability:|May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light sensitive. ||Important Note: |This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. ||Toxicity and Hazards: |All products should be handled by qualified personnel only, trained in laboratory procedures.

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