TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulation levels of platelets in vivo. The mouse TPO is a soluble protein containing 174aa residues, which comprises the receptor binding domain of the Mpl-ligand protein.||Source:|Recombinant protein corresponding to mouse TPO, expressed in E. coli. ||Molecular Weight: |~18.7kD||Biological Activity:|The ED50, as determined by the dose-dependent stimulation of the proliferation of human MO7e cells, is <1.0ng/ml, corresponding to a specific activity of >1x10e6units/mg.||Endotoxin:|<0.1ng/ug||Storage and Stability:|Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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