PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling.||Source:|Recombinant protein corresponding to human PTEN, expressed in E. coli.||Molecular Weight: |~80kD||Biological Activity:|A Phosphatase specific activity of ~400nmol/min/mg was determined using the substrate phosphatidylinositol (3,4,5) triphosphate at a final concentration of 125mM in 20mM Tris, pH 7.5, 150mM NaCl, 50mM MgCl2, 0.05% Tween-20, 0.2% 2-mercaptoethanol.||Endotoxin:|<0.1ng/ug||Storage and Stability:|Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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