Intracisternal A particle-promoted polypeptide (IPP) is a 66kD protein (584 amino acids), which|contains an N-terminal POZ protein-protein interaction domain and a C-terminla kelch repeat domain consisting of six tandem arranged repeats. The POZ domain (also called BTB domain) is present near the N-terminus of a fraction of zinc finger proteins and in protein that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-coR and SMRT. IPP-POZ domain (aa1-157) was overexpressed in E. coli.||Molecular Weight: |17.3kD (157 amino acids)||Sequence :|MANEDCPKAA/ DSPFSSDKHA/ QLILAQINKM/ RNGQHFCDVQ/ LQVGQESFKA/ HRLVLAASSP/|YFAALFTGGM/ KESSKDVVPI/ LGIEAGIFQI/ LLDFIYTGIV/ NIGVNNVQEL/ IIAADMLQLT/ EVVHLCCEFL/ KGQIDPLNCI/ GIFQFSEQIA/ CHDLLEF||Storage and Stability:|May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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