TGFbetaR2 is a member of the TGFbeta receptor subfamily and is a ser/thr protein kinase. TGFbetaR2-induced protein phosphorylation plays a key role in signal transduction that leads to mitogenic responses. The TGFbetaR2 receptor transmits signals from the cell surface to the nucleus and provides instructions for making transforming growth factor (TGF)-beta type II receptor. Mutations in TGFbetaR2 gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.||Source:|Recombinant protein corresponding to human TGFBR2, fused to GST-Tag at N-terminal expressed in Insect cells.||Molecular Weight:|~68kD||Specific Activity:|7nmol/min/mg as per activity assay protocol.||Endotoxin:|<1EU/ug (LAL)||Storage and Stability:|Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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