C-RPQIRQKIENKPLQE,fromtheinternalregionofhumanZEB1.|Controlpeptidecorrespondingtopolyclonalantibody,Catalog#Z0469-75A,goatxhuman.||ZEB1inhibitsinterleukin-2(IL-2)geneexpression.MayberesponsIBLefortranscriptionalrepressionoftheIL-2gene.EnhancesorrepressesthepromoteractivityoftheATP1A1genedependingonthequantityofCDNAandonthecelltype.DefectsinZEB1arethecauseofposteriorpolymorphouscornealdystrophytype3(PPCD3)[MIM:609141].Posteriorpolymorphouscornealdystrophy(PPCD)isararediseaseinvolvingmetaplasiaandovergrowthofcornealendothelialcells.InpatientswithPPCD,thesecellsmanifestinanepithelialmorphologyandgeneexpressionpattern,produceanaberrantbasementmembrane,and,sometimes,spreadovertheirisandnearbystructuresinawaythatincreasestheriskforglaucoma.||Applications:|SuitableforuseinELISA.Otherapplicationsnottested.||RecommendedDiltuinos:|Optimaldilutionstobedeterminedbytheresearcher.||StorageandStABIlity:|Maybestoredat4°Cforshort-termonly.Forlong-termstorageandtoavoidrepeatedfreezingandthawing,aliquotandstoreat-20°C.Aliquotsarestableforatleast12monthsat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.||PeptideBlocking(seecorrespondingantibodyZ0469-75A):|Antibodiesaretypicallysuppliedat0.5mg/mlandpeptidesasa100ulpellet.Whenpeptidesarereconstitutedin200ulwater,theconcentrationwouldbealso0.5mg/ml.Tostart,thebestratiowouldbe1:1(whichmeansmolarexcessofpeptidesrelativetoantibodieswhenidenticalvolumesaremixed).Mixequalvolumesofpeptideandantibodyattherequireddilutionandleaveatambienttemperature.Itisbestistohavetwoidenticalblots,tobeincubatedwithequalamountofantibodies,butonewiththeantibodiespre-adsorbedtothepeptidefor20min.Thenincubateanddevelopthetwoblotsinparallel.

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