Stromal Derived Growth Factor-1beta (SDF-1beta), also called CXCL12, is one of two splice variants made by a wide variety of cells when stimulated by inflammatory cytokines such as, TNF, IL-1 or LPS. SDF-1b signals through the G protein-couple receptor, CXCR4, to recruit activated leukocytes. ||Source:|Recombinant protein corresponding to feline SDF-1 beta, a non-glycosylated protein, comprised of 72aa, expressed in E. coli. ||Molecular Weight: |~8.5kD||Biological Activity:|Determined by its ability to chemoattract human T cells at 10-75ng/ml.||Endotoxin:|<0.01ng/ug||AA Sequence:|KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRF KM||Specificity:|Human SDF-1b shares 100% identity to feline SDF-1b. ||Storage and Stability:|Lyophilized powder may be stored at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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