Resistance to insulin characterizes type 2 diabetes, the most common form of diabetes. There is a strong link between type 2 diabetes and obesity, as most patients tend to be obese. Thiozolidinediones (TZDs), a new class of anti-diabetic, enhances target-tissue sensitivity to insulin. A screen of genes down regulated by TZD in adipocyte led to the discovery of a new protein hormone called resistin (for resistance to insulin). Resistin, specifically produced and secreted by adipocyte, is present at elevated levels in the blood of obese animals, and is down regulated by fasting and anti-diabetic drugs. Some other protein related to resistin has been called resistin-related molecules (RELM-alpha and beta). Resistin family of proteins was also identified as proteins (FIZZ1-3, for Found in Inflammatory zone) involved in allegory and inflammation.||Resistin is also described as serine/cysteine-rich Adipocyte-Specific Secretory Factor (ADSF or FIZZ3). Resistin (pre peptide length: human 108aa; mouse/rat 114aa; mol wt ~12.5kD) is characterized by the presence of a hydrophobic signal peptide that is cleaved before its secretion. Resistin proteins show ~55% homology in human and mouse. It is 45-55% related to RELM-alpha/FIZZ1/PMNG1 (Parasite-induced Macrophage Novel Gene 1). RELM-alpha mRNA was most abundant in white adipose tissue. It is also expressed in mammary tissue with significant fat pads. Unlike resistin, RELM-alpha is not expressed in 3T3-L1 adipocyte or in preadipocytes. It is also found in heart, lung and tongue, where resistin is absent. In mice, RELM-alpha/FIZZ1 is found at low levels in a subset of bronchial epithelial cells and in non- neuronal cells adjacent to neurovascular bundles in the peribronchial stroma, and in the wall of the large and small bowel.||Source:|Recombinant protein corresponding to 94aa from rat Resistin, fused to His-tag at N-terminal, expressed in E. coli.||Molecular Weight: |Homodimer of ~20kD in native state and ~11.9kD in denatured form.||Endotoxin:|<0.1ng/1ug of protein||AA Sequence:|MRGSHHHHHH GMASHMPSMS LCPMDEAISK KINQDFSSLL PAAMKNTVLH CWSVSSRGRL ASCPEGTTVT SCSCGSGCGS WDVREDTMCH CQCGSIDWTA ARCCTLRVGS 


 
  ||Storage and Stability:|Lyophilized powder may be stored at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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