Stem Cell Factor (SCF) is a hematopoietic growth factor that stimulates the proliferation of mast cells.  SCF also mediates cell-cell adhesion and acts synergistically with other cytokines. The actions of SCF are exerted by binding to the SCF Receptor (PE-1243-50) which results in receptor dimerization. SCF is a type I membrane glycoprotein with 5 potential N-linked glycosylation sites. Soluble SCF is produced by proteolytic cleavage of the extracellular domain. \t||Source:|Stem Cell Factor, from Human DNA sequence encoding the signal peptide and the mature Stem Cell Factor (SCF) protein of human SCF was expressed in modified human 293 cells.\t||Molecular Weight:|~20kD-42kD with post-translation modification and ~21kD unmodified||Biological Activity:|The ED50 of SCF is typically 10-20ng/ml as measured in a cell proliferation assay using the human growth factor-dependent M-07e cell line.\t||Storage and Stability:|Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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