Human RANKL is a member of the tumor necrosis factor superfamily. It primarily affects the immune system by controlling bone regeneration and remodeling. It functions in osteoclast differentiation and activation. It also is expressed by T helper cells as a factor in dendritic cell maturation and survival. It is expressed after T-cell activation. It also appears to have a role in the regulation of apoptosis through activation of the antiapoptotic kinase AKT/PKB. It is not only expressed by immune cells, but also on a number of other cells in the lung, thymus, skeletal muscle and many others. It can be expressed as a trimeric transmembrane protein, a secreted form or a truncated ectodomain. Human RANKL shares 85% sequence similarity with mouse RANKL.||Source:|Recombinant protein corresponding to human RANKL expressed in E. coli.||Molecular Weight:|~20kD||Endotoxin:|<1EU/ug (LAL)||Storage and Stability:|Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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