ControlPeptideforT2399-50(antiserum)andT2399-45(affinitypurified)||A21aaPeptidesequencemappinginthemiddleofhumanEst2.PeptidehasnosignificantsequencehomologywiththemouseEst2.||The3'endsofchromosomesarecappedwithtelomeresequences(TTAGGG;6-26nucleotidesinlength)byribonucleoproteintelomeraseduringDNAreplication.TelomeraseisanunusualRNA-dependentDNApolymerasethatusesandRNAcomponenttospecifytheadditionoftelomere.ThetelomericRNAcontainsasequencecomplementarytoTTAGGG.Inciliatedprotozoaandyeast,telomerelengthismaintainedbyregulatingtheactivityoftelomerase.Manymammaliancellsdonotexpresstelomeraseresultingintoshorteningoftelomerewitheachcelldivision,andultimatelycausingthechromosomalinstABIlity,agingandcelldeath.Approx.4.8kboftelomericDNAislostwitheachcelldivisionresultingintolargenumberofchromosomalabnormalities.Mostrecently,introductionoftelomeraseintonormalhumancellshasbeenshowntoextendnormalcelllifeby~20doubling.||Purificationoftelomerasefromtheciliatealsorevealedtwoproteinof43and123kD.p123isahomologofyeastEst2(EssentialforTelomeraseactivity).MammalianhomologsofyeastEst2(alsoknownasTP2forTelomeraseassociatedProtein2;hEST2ortelomerasecatalyticsubunitortelomerasereversetranscriptase,TERT)havealsobeencloned(humanEst2,1132aa;mouseEst21122aa;~127kD).hEST2waslocalizedinthenucleus.||Applications:|SuitableforuseinELISAforblockingexperiments.NotsuitableforWesternBlotduetolowMW:<3kD.Otherapplicationsnottested.||RecommendedDilution:|5-10ug/1ugofaffinitypureantibodyor1ulantiserum||StorageandStability:|Maybestoredat4°Cforshort-termonly.Forlong-termstorage,storeat-20°C.Aliquotsarestableforatleast6monthsat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.||ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplicationswithouttheexpressedwrittenauthorizationofUnitedStatesBIOLOGical.

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