Usbio/T2400-10抗端粒重复结合因子2，小鼠（TRF2，RAP2）（对照肽）/100ug/T2400-10
商品编号：
T2400-10
品牌：
USbiological
市场价：
¥6940.00
美元价：
2949.50
产品分类：
氨基酸
公司分类：
aminophenol
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
A21aaPeptidesequenceneartheC-terminusofMouseTRF2.The21AAmousecontrolpeptidehasnosignificantsequencehomologywithTRF1.||The3'endsofchromosomesarecappedwithtelomeresequences(TTAGGG;6-26nucleotidesinlength)byribonucleoproteintelomeraseduringDNAreplication.TelomeraseisanunusualRNA-dependentDNApolymerasethatusesandRNAcomponenttospecifytheadditionoftelomere.ThetelomericRNAcontainsasequencecomplementarytoTTAGGG.Inciliatedprotozoaandyeast,telomerelengthismaintainedbyregulatingtheactivityoftelomerase.Manymammaliancellsdonotexpresstelomeraseresultingintoshorteningoftelomerewitheachcelldivision,andultimatelycausingthechromosomalinstABIlity,agingandcelldeath.Approx.4.8kboftelomericDNAislostwitheachcelldivisionresultingintolargenumberofchromosomalabnormalities.||Purificationoftelomerasefromtheciliatealsorevealedtwoproteinof43and123kD.p123isahomologofyeastEst2(EssentialforTelomeraseactivity).MammalianhomologsofyeastEst2(alsoknownasTP2forTelomeraseassociatedProtein2;hEST2ortelomerasecatalyticsubunitortelomerasereversetranscriptase,TERT)havealsobeencloned(humanEst2,1132aa;mouseEst21122aa;~127kD).(1).||TelomericRepeatbindingFactors(TRF1andTRF2)bindthetelomericTTAGGGrepeat.TRFshavebeencolocalizedwithtelomericDNAinmetaphasecells.TRFsarelocatedatchromosomeendsduringmetaphase.MouseandhumanTRF2are495aaand500aa,respectively.TRF1andTRF2share~30%homology.
品牌介绍
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