A19aaPeptidesequenceinthemiddleportionofMouseTP1.The19AAmousecontrolpeptideis100%homologouswithratand89%withhumanTP1||The3'endsofchromosomesarecappedwithtelomeresequences(TTAGGG;6-26nucleotidesinlength)byribonucleoproteintelomeraseduringDNAreplication.TelomeraseisanunusualRNA-dependentDNApolymerasethatusesandRNAcomponenttospecifytheadditionoftelomere.ThetelomericRNAcontainsasequencecomplementarytoTTAGGG.Inciliatedprotozoaandyeast,telomerelengthismaintainedbyregulatingtheactivityoftelomerase.Manymammaliancellsdonotexpresstelomeraseresultingintoshorteningoftelomerewitheachcelldivision,andultimatelycausingthechromosomalinstABIlity,agingandcelldeath.Approx.4.8kboftelomericDNAislostwitheachcelldivisionresultingintolargenumberofchromosomalabnormalities.||Purificationoftelomerasefromtheciliatealsorevealedtwoproteinof43and123kD.p123isahomologofyeastEst2(EssentialforTelomeraseactivity)andshow20%homology.MammalianhomologsofyeastEst2(alsoknownasTP2forTelomeraseassociatedProtein2;hEST2ortelomerasecatalyticsubunitortelomerasereversetranscriptase,TERT)havealsobeencloned.Est2isassociatedwithtelomeraseactivityandTP1.Mouse/ratandhumanTP1are2627and2629aaproteins,respectively.||Applications:|SuitableforuseinELISAandAntibodyBlocking.NotsuitableforWesternBlotduetolowMW.Otherapplicationsnottested.||RecommendedDilution:|ELISA:1ug/mltocoatplates.|AntibodyBlocking:5-10ugpeptide.|Optimaldilutiondeterminedbytheresearcher.||StorageandStability:|Maybestoredat4°Cforshort-termonly.Forlong-termstorage,aliquotandstoreat-20°C.Aliquotsarestableforatleast6monthsat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.

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