Oncostatin M (OSM) is an important growth regulating cytokine that affects, variably, a number of tumor and normal cells. Oncostatin M exerts inhibitory effects on the growth of A375 melanoma and other cells, but augments the growth of normal fibroblasts, AIDS-related Kaposi sarcoma cells, and certain other cells. ||Source:|Recombinant protein corresponding to 227aa residues from human Oncostatin M, expressed in E. coli. ||Molecular Weight: |~26kD||Biological Activity:|The ED50, as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells, is <2ng/ml, corresponding to a specific activity of >5x10e5units/mg.||Endotoxin:|<0.1ng/ug||Storage and Stability:|Lyophilized powder may be stored at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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