High in Normal-1 also known as Uteroglobulin related protein 2 (UGRP2), is an 8kD secreted protein of the secretoglobin superfamily (SCGB3A1). HIN-1 is expressed in bronchial epithelial and secretory Clara cells, mammary epithelial cells (particularly during pregnancy), salivary glands, and the prostate. It is up-regulated in Clara cells by IL-4, IL-13, Oncostatin M, EGF, and TGF-a and down-regulated by IFNa B, and g. It is secreted into bronchial lavage fluid, saliva, and plasma and may form disulfide-linked dimers. HIN-1 binds to the macrophage scavenger receptor MARCO and to the surface of mammary and bronchial epithelial cells. HIN-1 promotes apoptosis and inhibits the proliferation, migration, and invasion of breast cancer cells likely through the Akt signaling pathway. The down-regulation of HIN-1 expression in many breast, lung, and prostate cancers correlates with hypermethylation of its promoter. Mature mouse HIN-1 shares 58% and 93% aa sequence identity with human and rat HIN-1, respectively. A variant of mouse HIN-1 has a substitution at the N-terminus in place of its potential signal peptide.||Source:|Recombinant corresponding to aa22-104 from mouse HIN-1expressed in E.coli. ||Molecular Weight:|~8.4kD||Activity:|Measured by the ability of the immobilized protein to support the adhesion of the A549 human lung carcinoma cell line. The ED50 for this effect is typically 0.5-2.5ug/ml||Endotoxin: ~1EU/1ug (LAL)||Storage and Stability:|Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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