Human 4-BBL or TNFSF9 is a member of the TNF superfamily. It is a type 2 transmembrane protein expressed on activated T-cells. It is a bidirectional signal transducer which acts as a costimulatory receptor molecule on T lymphocytes. Its functions primarily stimulate the immune response by promoting the release of cytokines such as IL-2 and IFN-gamma. TNFSF9 works with TNFRSF9 for the generation of cytotoxic T cells, proliferation of T-cells as well as antigen presentation. It also reactivates T lymphocytes which have become anergic. It is also expressed on activated NK cells, B-cells, macrophages, dendritic cells and some brain cells. Recombinant Human 4-BBL is a 19.6kD protein.||Source:|Recombinant protein corresponding to human 4-BBL expressed in E. coli.||Molecular Weight:|~19.6kD||Endotoxin:|<1EU/ug (LAL)||Storage and Stability:|Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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