NVP-BEZ235 is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.NVP-BEZ235 is able to effectively and specifically block the dysfunctional activation of the PI3K pathway and induce G(1) arrest. It also inhibits the growth of human cancer in animal models.||Solubility:|Soluble in anhydrous dimethylformamide at 10mg/ml after warming to 75ºC and cooling; soluble in DMSO at 1.33mg/ml with warming; soluble in 1-methyl-2-pyrrolidinone at about 2mg/ml if heated in a 75ºC bath and cooled; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20uM; buffers, serum or other additives may increase or decrease the aqueous solubility.||Melting Point:|282.5-285ºC||Elemental Analysis:|Calculated|C: 76.74%|H: 4.94%|N: 14.92%||Storage and Stability:|May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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