Prostanoids are the cyclooxygenase metabolites derived from C-20 unsaturated fatty acids (arachidonic acid) and include prostaglandin (PG) D2, PGE2, PGF2 alpha, PGI2, and thrombaxane (Tx) A2. Prostaglandin F(2-alpha) is involved in a number of physiologic processes. It serves as a potent luteolytic agent in many species, has been implicated as a modulator of intraocular pressure, and may be important in smooth muscle contraction in the uterus and elsewhere. Its effects on cells are mediated through specific interaction with prostaglandin receptors (PTGFRs, PTGF2- alpha or PF2R). Human PF2R is a 359aa (calculated mo wt of ~40kD). It has 7 putative transmembrane domains characteristic of the G protein-coupled receptors. As expected, expression studies of the cDNA in Xenopus oocytes and COS cells showed strongest binding to PGF(2- alpha). It has been , mapped the gene to 1p31.1. PF2R knockout mice are unable to deliver normal fetuses at term due to a lack of response to oxytocin. The mice also failed to show the decline in serum progesterone expected to precede parturition. However, if the mice had their ovaries removed at day 19 of pregnancy, normal delivery occurred. Therefore, parturition may be initiated when prostaglandin F(2-alpha) interacts with its receptor in ovarian luteal cells to induce luteolysis. Rat PF2R expression has been detected in astrocytes and whole brain and pregnant ovary.||Source:|Synthetic peptide corresponding to 18aa from CP3 of mouse PF2R (Accession #Q9D627) and a 19aa C-terminal (PF2R2) peptides of rat PF2R (Accession #P43118).||Molecular Weight:|~3kD||Applications:|Suitable for use in ELISA and Antibody Blocking. Not suitable for Western Blot. Other applications not tested.||Recommended Dilution:|ELISA: 5-10ug control peptide per 1ug of aff pure IgG or 1ul antiserum)|Optimal dilutions to be determined by the researcher.||Storage and Stability:|Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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