Adrenocorticotropichormone(ACTH),alsoknownascorticotropin,isapolypeptidetropichormoneproducedandsecretedbytheanteriorpituitarygland.Itisanimportantcomponentofthehypothalamic-pituitary-adrenalaxisandisoftenproducedinresponsetoBIOLOGicalstress(alongwithcorticotropin-releasinghormonefromthehypothalamus).Itsprincipaleffectsareincreasedproductionandreleaseofcorticosteroidsand,asitsnamesuggests,cortisolfromtheadrenalcortex.||ACTHissynthesizedfrompre-pro-opiomelanocortin(pre-POMC).Theremovalofthesignalpeptideduringtranslationproducesthe241-aminoacidpolypeptidePOMC,whichundergoesaseriesofpost-translationalmodificationssuchasphosphorylationandglycosylationbeforeitisproteolyticallycleavedbyendopeptidasestoyieldvariouspolypeptidefragmentswithvaryingphysiologicalactivity.ThesefragmentsincludeNPP,MelanotropinGamma(y-MSH),PotentialPeptide,Corticotropin(AdrenocorticotropicHormone,orACTH),MelanotropinAlpha(Melanocyte-StimulatingHormone,oralpha-MSH),Corticotropin-likeIntermediatePeptide(CLIP),LipotropinBeta(b-LPH),LipotropinGamma(y-LPH),MelanotropinBeta(b-MSH),Beta-Endorphin,andMet-Enkephalin.POMC,ACTHandbeta-lipotropinaresecretedfromcorticotropesintheanteriorlobe(oradenohypophysis)ofthepituitaryglandinresponsetothehormonecorticotropin-releasinghormone(CRH)releasedbythehypothalamus.||InordertoregulatethesecretionofACTH,manysubstancessecretedwithinthisaxisexhibitslow/intermediateandfastfeedback-loopactivity.GlucocorticoidssecretedfromtheadrenalcortexworktoinhibitCRHsecretionbythehypothalamus,whichinturndecreasesanteriorpituitarysecretionofACTH.GlucocorticoidsmayalsoinhibittheratesofPOMCgenetranscriptionandpeptidesynthesis.Thelatterisanexampleofaslowfeedbackloop,whichworksontheorderofhourstodays,whereastheformerworksontheorderofminutes.||ACTHisalsorelatedtothecircADIanrhythminmanyorganisms.Thehalf-lifeofACTHinhumanbloodisabouttenminutes.||MolecularWeight:|~4541.16||Sequence:|Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe||StorageandStABIlity:|Lyophilizedpowdermaybestoredat-20°C.Stablefor12monthsafterreceiptat-20°C.ReconstitutewithsterilebufferorddH2O.Aliquottoavoidrepeatedfreezingandthawing.Storeat-20°C.Reconstitutedproductisstablefor6monthsat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.

usbio的生化试剂，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。 恭喜苏州蚂蚁淘获得usbio2020年授权书，成为usbio中国代理，购买usbio,请认准usbio代理-苏州蚂蚁淘！