Thefunctionofthedelta-opioidreceptorshasnotbeendetermined.However,recentstudiesinrodentshavelinkeddelta-opioidreceptorantagoNISTswithpreventionofmorphinetoleranceanddependencewithoutrelinquishingmu-opioidantinociception.Ingeneral,opioidsmodulatenumerouscentralandperipheralprocesses,includingpainperception,neuroendocrinesecretionandtheimmuneresponse.TheopioidsignalistransducedfromreceptorsthroughGproteinstovariousdifferenteffectors.SubsequenttoGproteinactivation,severaleffectorsareknowntoorchestratetheopioidsignal.Forexample,activationofopioidreceptorsincreasesphosphatidylinositolturnover,activatesK+channelsandreducesadenylylcyclaseandCa++channelactivities.||Sequence(linear):Ac-Cys-Gly-Arg-Gln-Glu-Pro-Gly-Ser-Leu-Arg-Arg-Pro-Arg-Gln-Ala-NH2||AminoAcidAnalysis:Confirmsexpectedsequence|PeptideContent:80.3±4%||Solubility:H2O||StorageandStABIlity:|Lyophilizedpowdermaybestoredat4°Cforshort-termonly.Stablefor12monthsat-20°C.Reconstitutetonominalvolume(seereconstitutioninstructionsforpeptides)andstoreat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.|||

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