Control of appetite involves a number of gastrointestinal hormones that belong to the Ghrelin-motilin ligand family that either stimulate food intake and gastric emptying or inhibit these responses.||Obestatin, a ghrelin-associated peptide, has recently been discovered by searching for orthologs of the human ghrelin gene and after comparison of preproghrelin sequences from 11 mammalian species. In addition to the known ghrelin peptide, which immediately follows the signal peptide, the researchers identified another conserved region. This region was flanked by a potential convertase cleavage site, which originated a putative 23aa peptide, with a flanking conserved glycine residue at the C- terminal, suggesting that it might be amidated.||Interestingly, Des 1-10 Obestatin (C-terminal 11-23aa) - a truncated peptide of obestatin was shown to have a lower binding affinity to its receptor GPR39 as compared to the full length obestatin. GPR39 mRNA is prominently expressed in the ventral hippocampus, specifically the CA1, which is known to project to the basolateral and basomedial amygdaloid nuclei, which also express GPR39 mRNA. Contextual conditioning is disrupted when any of these nuclei are damaged, indicating that activation of the GPR39 system may modulate this response.||Reports that GPR39 is a cognate receptor for Obestatin were recently contradicted warning for more prudent approach to investigation.||Source:|Synthetic peptide corresponding to 1-23aa of mouse/rat Obestatin, full-length.||AA Sequence:|F-N-A-P-F-D-V-G-I-K-L-S-G-A-Q-Y-Q-Q-H-G-R-A-L-NH2||Molecular Weight:|2520.76||Solubility:|Soluble in dH2O||Storage and Stability:|Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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