A20-aapeptidesequencewithintheCytoplasmic,C-terminusofhumanMCT7.||Monocarboxylatesuchaslactateandpyruvateplayanimportantroleincellularmetabolism.Lacticacidisproducedastheendproductofglycolysis.Sometissues,suchaswhiteskeletalmuscleand,redbloodcells,usethispathwaytogeneratemostoftheirATPundernormalphysiologicalconditions.Alltissuesbecomedependentonthispathwayduringabnormalconditionssuchashypoxiaandischaemia.Lacticacid,producedduringnormalglycolysis,mustbetransportedoutofcellstosustainmaintainhighrateofglycolysis.FailuretoexportlacticacidleadstoaccumulationofcellularlacticacidfollowedbyanincreaseinpHandinhibitionofglycolysis.Sometissues,suchasbrain,heart,andredskeletalmuscle,reADIlyoxidizelacticacid,andmustimportlacticacidintothecells.Lacticacidtransportismediatedbyagroupofproton-linkedmembranetransporterscalledmonocarboxylicacidtransporters(MCTs).Atleast9MCT-relatedproteins(MCT1-9)havebeenidentifiedinmammalsthatareexpressedinatissuespecificmanner.||MCT7/MOT7/SLC16A6(mouse,523-aa;human423-aa,chromosome17q25.1)isanewmemberofMCTfamily.Accordingtonewnomenclature,theoldMCT6hasnowbeenreclassifiedasMCT7.ThisantibodyhaspreviouslybeenlistedasMCT62-S.PleaseconsultthemainMCTpagefordetailsonthenewnomenclature.

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