A 19-aa peptide sequence within the Cytoplasmic loop # 4 of human MCT5.||Monocarboxylate such as lactate and pyruvate play an important role in cellular metabolism. Lactic acid is produced as the end product of glycolysis. Some tissues, such as white skeletal muscle and, red blood cells, use this pathway to generate most of their ATP under normal physiological conditions. All tissues become dependent on this pathway during abnormal conditions such as hypoxia and ischaemia. Lactic acid, produced during normal glycolysis, must be transported out of cells to sustain maintain high rate of glycolysis. Failure to export lactic acid leads to accumulation of cellular lactic acid followed by an increase in pH and inhibition of glycolysis. Some tissues, such as brain, heart, and red skeletal muscle, readily oxidize lactic acid, and must import lactic acid into the cells. Lactic acid transport is mediated by a group of proton-linked membrane transporters called monocarboxylic acid transporters (MCTs). At least 9 MCT-related proteins (MCT1-9) have been identified in mammals that are expressed in a tissue specific manner.||MCT5/SLC16A4 (mouse 468-aa, human 487-aa, chromosome 1p13.1) shares 25% sequence homology with MCT1, but it has much shorter C-terminus than other MCTs. MCT5 has an Alu insertion even in the 3'-UTR and a truncated C-terminus. High expression of MCT5 has been observed in placenta. According to new nomenclature, the old MCT4 has now been reclassified as MCT5. This antibody has previously been listed as MCT42-S. Please consult the main MCT page for details on the new nomenclature.

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