Exodus-2, also known as CCL21 and 6Ckine, is a novel chemokine produced at high levels in human lymph node tissue and the spleen. 6Ckine signals through the CCR7 receptor to recruit thymocytes and activated T cells in vitro, but is not known to be chemotactic for monocytes. Human and mouse Exodus-2 share > 85% aa homology. Recombinant mouse Exodus-2 is a nonglycosylated protein, containing 110aa, with a molecular weight of 12kD.||Source:|Recombinant protein corresponding to 10aa from mouse Exodus-2, expressed in E. coli.||Molecular Weight:|~12kD||Biological Activity:|Determined by its ability to chemoattract 5-10 day old cultures of human peripheral blood lymphocytes at concentrations between 200ng/ml- 600ng/ml.||Amino Acid Sequence:|SDGGGQDCCL KYSQKKIPYS IVRGYRKQEP SLGCPIPAIL FSPRKHSKPE LCANPEEGWV QNLMRRLDQP PAPGKQSPGC RKNRGTSKSG KKGKGSKGCK RTEQTQPSRG||Endotoxin:|<0.1ng/ug||Storage and Stability:|Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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