CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF b1, and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans CTGF (98aa), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. ||Recombinant protein corresponding to 98aa residues from human CTGF, expressed in E. coli. ||Biological Activity:|ED50 is 1-2ug/ml determined by the dose-dependent stimulation of the proliferation of HUVEC cells.||Storage and Stability:|Lyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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