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当前位置: 首页 > 产品中心 > Other_recombinant_protein > Usbio/209019 Anti-Hypoxia Inducible Factor 1 Alpha, Recombinant, Human, aa530-826 (HIF-1a)/10ug/209019
商品详细Usbio/209019 Anti-Hypoxia Inducible Factor 1 Alpha, Recombinant, Human, aa530-826 (HIF-1a)/10ug/209019
Usbio/209019  Anti-Hypoxia Inducible Factor 1 Alpha, Recombinant, Human, aa530-826 (HIF-1a)/10ug/209019
Usbio/209019 Anti-Hypoxia Inducible Factor 1 Alpha, Recombinant, Human, aa530-826 (HIF-1a)/10ug/209019
商品编号: 209019
品牌: USbiological
市场价: ¥9780.00
美元价: 4156.50
产地: 美国(厂家直采)
公司:
产品分类: 其它重组蛋白
公司分类: Other_recombinant_protein
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in cellular and systemic oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1 subunit and one of three subunits (Hif-1, Hif-2 or Hif-3). The activation of Hif-1 (is closely associated with a variety of tumors and oncogenic pathways. Hif-1 (consists of DNA binding domain (DBD domain), Dimerization domain and C-terminal regulatory domains, including two transactivation domains (TAD), an oxygen-dependent degradation (ODD) domain, and inhibitory domains. Under hypoxic conditions HIF1A activates the transcription of more than 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, VEGF, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1A also plays a crucial role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.||Source:|Recombinant protein corresponding to human HIF-1a, a single, non-glycosylated polypeptide chain containing 298aa (aa530-826), expressed in E. coli.||Molecular Weight: |~32.8kD, the protein migrates as a ~40kD band on SDS-PAGE||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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