Cntfr, also known as ciliary neurotrophic factor receptor subunit alpha, is a member of the type 1 cytokine receptor family. It mediates the biological action of CNTF. CNTF is a polypeptide hormone that supports the survival of neurons of the peripheral sensory, sympathetic, and ciliary ganglia at various stages in their development. CNTFR and its cognate ligand support the survival of neurons. The CNTF receptor complex is most closely related to, and shares subunits with the receptor complexes for interleukin-6 and leukemia inhibitory factor. The specificity conferring alpha subunit of the CNTF complex (CNTFR alpha), is extremely well conserved across species, and has a distribution localized predominantly to the nervous system and skeletal muscle. ||Source:|Recombinant protein corresponding to aa23-342 from rat CNTFR, fused to His-Tag at C-terminal, expressed in insect cell.||Molecular Weight: |~36.9kD (328aa), 40-57kD (SDS-PAGE under reducing conditions.)||Endotoxin: |<1EU/1ug (determined by LAL method)||AA Sequence:|QKHSPQEAPH VQYERLGTDV TLPCGTASWD AAVTWRVNGT DLAPDLLNGS QLILRSLELG HSGLYACFHR DSWHLRHQVL LHVGLPPREP VLSCRSNTYP KGFYCSWHLS APTYIPNTFN VTVLHGSKMM VCEKDPALKN RCHIRYMHLF STIKYKVSIS VSNALGHNTT AITFDEFTIV KPDPPENVVA RPVPSNPRRL EVTWQTPSTW PDPESFPLKF FLRYRPLILD QWQHVELSNG TAHTITDAYA GKEYIIQVAA KDNEIGTWSD WSVAAHATPW TEEPRHLTTE AQAPETTTST TSSLAPPPTT KICDPGELSS LEHHHHHH||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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