ControlPeptidefor(affinitypurified)and(antiserum).|Syntheticpeptide,A13aapeptidemappingattheN-terminusofmaturemousedefensin-3anda15-aapeptidemappingattheN-terminusofmaturehumandefensin-3weresynthesizedforantibodyproduction.||Antimicrobialpeptidesareacommonmechanismofhostdefenseutilizedbyavarietyofspecies,frominsectstohumans.Defensinsarealargefamilyofbroad-spectrumantimicrobialpeptides,identifiedoriginallyinleukocytesofrabbitsandhumans.Defensins,cationic/polarpeptides(30-35aa;3-4kD),aredistinguishedbyaconservedtri-disulfidesandalargelyb-Sheetstructure.Defensins,expressedatthecellsurface,havebeenhypothesizedtofunctionasabiochemicalbarrieragainstmicrobialinfectionbyinhibitingcolonizationoftheepitheliumbywiderangeofpathogenicmicroorganisms.Inleukocytes,thesepeptidesarestoredincytoplasmicgranulesandarereleasedintophagolysosomeswheretheycontributetothekillingofengulfedmicroorganisms.||Thegenesencodinghumanaandb-defensinsareclusteredinacontiguoussegmentofchromosome8p23.Defensinsareclassifiedintotwofamiliesdesignateda–andb-basedondistinctive,althoughsimilar,tri-disulfidelinkagesinthepeptides.b-defensinsareslightlylargeranddifferinthepositionandarrangementof3disulfides.Inhumans,sixa–defensin(cryptidins),HD1-6(HD1-4arealsoknownasHNP1-4forHumanNeutrophilPeptides),andtwob-defensins,HBD-1andHBD-2,havebeenidentifiedtodate.Rat(RBD-1andRBD-2)andmouse(MBD1-4)homologuesofthehumanbeta-defensinhavealsobeenidentified.||Source:|Humanbeta-defensin-3isproducedfrom67aapeptideprecursor(maturepeptide23-67aa).Mousebeta-defensin-3isproducedfroma63aapeptideprecursor(maturepeptide23-63aa).||Applications:|SuitableforuseinELISAandAntibodyBlocking.NotsuitableforWesternBlotduetolowMW.Otherapplicationsnottested.||RecommendedDilution:|ELISA:1ug/mltocoatplates.|AntibodyBlocking:5-10ugpeptide.|Optimaldilutiondeterminedbytheresearcher.||StorageandStABIlity:|Maybestoredat4°Cforshort-termonly.Forlong-termstorage,storeat-20°C.Aliquotsarestableforatleast6monthsat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.

usbio的生化试剂，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。 恭喜苏州蚂蚁淘获得usbio2020年授权书，成为usbio中国代理，购买usbio,请认准usbio代理-苏州蚂蚁淘！