Noggin is a secreted homodimeric glycoprotein that binds to ligands of the TGF-beta family (BMPs) and regulates their activity by inhibiting their access to signaling receptors. Mature human Noggin protein contains an N-terminal acidic region, a central basic heparin-binding segment and a C-terminal cysteine knot structure. Noggin binds different BMPs with variable affinities, antagonizing specific BMPs during skeletal development. Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin. Recombinant Human Noggin expressed in human 293 cells is a glycosylated, disulfide linked homodimer with a molecular weight of 65kD.||Source:|Recombinant protein corresponding to human Noggin expressed in HEK293.||Molecular Weight:|~65kD||Biological Activity:|The EC50 as determined by the dose-dependent inhibition of rh-BMP-4 induced alkaline phosphate production by ATDC5 cells was found to be ≤25ng/mL.||Endotoxin:|<1EU/ug (LAL)||Storage and Stability:|Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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