Human TWEAK is a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. TWEAK, like many other members of the TNF family, is able to induce interleukin-8 synthesis in a number of cell lines. The recombinant human TWEAK comprises the TNF-like extraCellular domain of TWEAK||Source:|Recombinant protein corresponding to human TWEAK, expressed in E. coli. ||Molecular Weight: |~17kD||Biological Activity:|The ED50, as determined by the dose-dependent stimulation of IL-8 production by human PBMC, is <10ng/ml.||Endotoxin:|<0.1ng/ug||Storage and Stability:|Lyophilized powder may be stored at -20°C. Reconstitute with sterile sodium phosphate. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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