Adipocyte Fatty Acid Binding Protein (A-FABP), also known as FABP4, aP2 and ALBP, is a 15kD protein and is one of the most abundant proteins in mature adipocytes. Human and mouse A-FABP share 91% amino acid sequence homology. Several adipokines from adipose tissues have been identified. They mediate the cross talk between adipose tissue and the cardiovascular system. This interaction between adipose tissue, macrophages and several inflammatory cells leads to expression of, besides A-FABP, among others TNF-alpha, IL-6, MCP-1, leptin, lipocalin-2 and Pai-1. A-FABP is expressed in macrophages and lymphocytes. A-FABP plays a role in the intracellular utilization of fatty acids, transport and metabolism. The putative function of A-FABP is to serve as a lipid-binding chaperone for fatty acids. The protein was identified as a cytoplasmic protein, but is also described to be secreted by adipose tissue in the bloodstream. A-FABP have closely been associated with metabolic syndrome, obesity and atherosclerosis. It is considered as a therapeutic target for these processes in animal models. Several groups have demonstrated an association between serum levels of A-FABP and obesity-related cardiometabolic risk factors, endothelial dysfunction and macrovascular complications of diabetes. The proatherogenic activity of A-FABP is mediated by its direct actions on macrophages, independently of lipid metabolism and insulin sensitivity. In line with clinical findings, data from animal studies also supports a role of A-FABP in cardiovascular disease.||Source:|Recombinant protein corresponding to mouse FABP4 expressed in E. coli. ||Molecular Weight: |~15kD||Recommended Dilution:|Use protein stabilized PBS, pH 7.4. |Optimal dilutions to be determined by the researcher.||Storage and Stability:|Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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