IBSP, also known as bone sialoprotein 2, is a monomeric noncollagenous member of the SIBLING family of extracellular matrix (ECM) proteins. It is synthesized by platelets, osteoblasts, osteocytes, odontoblasts, osteoclasts, and bone marrow stromal cells. It is a key mediator of the hypertrophic chondrocytes-induced angiogenesis. It was associated with the severity of histological cartilage lesions and with vascular density at the osteochondral junction. ||Source:|Recombinant protein corresponding to aa17-317 from human IBSP, fused to his-Tag at C-terminal, expressed in insect cell.||Molecular Weight: |~34.5kD (309aa) 70-100kD (SDS-PAGE under reducing conditions)||Endotoxin:|~1EU/1ug (LAL)||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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