Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE (summary by Milatovich et al., 1994 [PubMed 8009369]).||Source:|Recombinant corresponding to aa2-825 from human PDE4A10, fused to GST-tag at N-terminal, expressed in a Baculovirus infected Sf9 cell expression system.||Molecular Weight:|~117kD||Applications:|Suitable for use in the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Specific Activity:|~29,021pmol/min/ug||Storage and Stability:|Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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