HDAC6 is a Class II HDAC. It is unique among human HDACs in having two full deacetylase domains. As a tubulin deacetylase, HDAC6 may act to promote autophagic clearing of Huntington aggregates and retard HIV1 infection. It can shuttle between the nucleus and cytoplasm, suggesting potential extra nuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.||Source:|Recombinant protein corresponding to human HDAC6, fused to GST tag expressed in Baculovirus.||Molecular Weight: |~159kD||Biological Activity:|560 pmole/min/ug. Assay conditions: 25mM Tris/HCl, pH 8.0, 137mM sodium chloride, 2.7mM KCl, 1mM MgCl2, and 0.1mg/ml BSA, 20um HDAC substrate, and HDAC6 (7.8-500ng). Incubation condition: 30 min at 37ºC followed by developing for 15 min at RT.||Endotoxin:|<1EU/ug (LAL method)||Storage and Stability:|Aliquot to avoid repeated freezing and thawing and store at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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