TheprostanoidfamilyincludesPGD2,PGE2,PGF2alpha,PGI2,thromboxaneA2andprostaglandins.Theprostaglandins(PGs)areimplicatedinvariousphysiologicalandpathophysiologicalevents,includingmalefertility,menstruation,ovulation,pregnancy,implantationandinflamatoryandneoplasticdiseases.||ThebiosynthesisofPGsandsomeotherprostanoidsiscatalyzedinaratelimitingstepbyPG-Hsynthase(alsoknownascyclooxygenase(COX),PG-endoperoxidasesynthase(PTGS))whichconvertsarachidonicacidtoprostaglandin/prostanoidprecursorPGH2.Twocyclooxygenaseisozymes,COX1(human,576aa,69-72kD;chromosome9)andCOX2(human,604aa,74kD;chromosome1)havebeenidentified.||COX1,aconstitutivelyexpressedisoform,producesphysiologicallyrelevantprostanoidssuchasthoseinstomachandplatelets.COX2isoformisinducIBLeandrapidlyupregulatedatinflamationsitesandformsproinflamatoryprostanoids.TheoverexpressionofCOX-2alsoleadstotumerogenesis.Recently,athirdisoformCOX3(canine633aa;~65kDinhumanaorta)hasbeenreported.TwosmallerCOX1-derivedproteins(partialCOX1)PCOX1a(canine414aa,~53kDinhumanaorta)andPCOX1bhavealsobeencharacterized.TheCOX3,butnotPCOX1a,possessesglycosylationdependentcyclooxygenaseactivity.||Thenonsteroidalantiinflammatorydrugs(NSAIDs)reducetheformationofprostaglandinsbyinhibitingtheactivityofcyclooxygenases(COX1,COX2andCOX3),ThisABIlitywasassociatedwithinhibitionofCOX,whichconvertsarachidonicacidtotheprostaglandinprecursorprostaglandinH2.||Thisplasmid,whichcontains2.3KbupstreamandthemousePGHS-1promoter,clonedintothePromegapGLbasicluciferasereporterplasmid.Upontransfection,thisconstructcanbeusedtoinvestigatePGHS-1generegulation.||StorageandStability:|Stableat-20°C.Avoidrepeatedfreeze/thawcycles.

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