ControlpeptideforP3342-10(affinitypurifiedantibody)andP3342-10A(antiserum).||SeveralendogenousfactorshavebeenlinkedtorhythmicityorcircADIanbehavioroflivingorganisms.InDrosophila,thegenesperiod(dPer)andtimeless(tim),andinNeurosporafrequency(frq),havebeenproposedtoberesponsIBLefortheircircadianrhythm.Recentlyhumanandmousegenesencodingabasichelix-loop-helix(bHLH)andPer-ARNT-Sim(PAS)-domainwithsignificantsimilaritytotheDrosophilaPeriodhavebeenreported.TheCDNAsequencesofhPERandmPer1(alsonamedRIGUI)arepredictedtoencodeforproteinsoflength1290and1291aminoacidsrespectively.HomologuesofmPer1designatedPer2(1257aa)andPer3(1113aa)havealsobeencloned.BothPer1andPer2levelsshowcircadianrhythmintheSCNandeyes.IthasbeensuggestedthatmPerregulatesneuronalactivityintheSCN.Usinggeneticapproach,asinglemutation(AtoTintheClockgeneaffectscircadianrhythmicityinmice.Clockhasbeenmappedtochromosome5.MouseClockencodesatranscriptionfactor,asinglepolypeptidechainof855aa(predictedcalculatedmolwt~97kD;pI6.52;hClock,846aa).Clockisabundantlyexpressedinbrain(SCN,pyrifomcortex,hippocampus)aswellasinothertissues(eye,totalbrain,tested,ovaries,liver,heart,lung,andkidney).Although,Clockisconstitutivelyexpressed(notrhythmic)intheSCN,itmaystillbeanimportantcomponentofcircadianmachinery.||Applications:|SuitableforuseinELISAandAntibodyBlocking.NotsuitableforuseinWesternBlot.Otherapplicationsnottested.||RecommendedDilution:|AntibodyBlocking:Use5-10ugper1ugofaffinitypurifiedantibody(P3342-10)or1ulofantiserum(P3342-10A).||ELISA:50-100ngcontrolpeptideperwell.||Optimaldilutionstobedeterminedbytheresearcher.||StorageandStABIlity:|Maybestoredat4°Cforshort-termonly.Forlong-termstorage,storeat-20°C.Aliquotsarestableforatleast6monthsat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.

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