ControlPeptideM(1)EQPQEETPEAREE(14)C(linear)forP5505-04anti-PPARd(PeroxisomeProliferatorActivatedReceptor,delta)whichdetectsperoxisomeproliferatoractivatedreceptor(PPAR)deltafrommousetissuesandcells,butnotdetectPPARalphaorPPARgamma.||Peroxisomeproliferatorsarenon-genotoxiccarcinogenswhicharepurportedtoexerttheireffectoncellsthroughtheirinteractionwithmembersofthenuclearhormonereceptorfamily,termedperoxisomeproliferatoractivatedreceptors(PPARs).Nuclearhormonereceptorsareligand-dependentintracellularproteinsthatstimulatetranscriptionofspecificgenesbybindingtospecificDNAsequencesfollowingactivationbytheappropriateligand.StudiesindicatethatPPARsareactivatedbyperoxisomeproliferatorssuchasclofibricacid,nafenopin,andWY-14,643,aswellasbysomefattyacids.IthasalsobeenshownthatPPARscaninducetranscriptionofacylcoenzymeAoxidase&cytochromeP450A6(CYP450A6)throughinteractionwithspecificresponseelements.PPARalphaisactivatedbyfreefattyacidsincludinglinoleic,arachidonic,andoleicacids.Inductionofperoxisomesbythismechanismleadstoareductioninbloodtriglyceridelevels.PPARalphaisexpressedmainlyinskeletalmuscle,heart,liver,andkidneyandisthoughttoregulatemanygenesinvolvedinthebeta-oxidationoffattyacids.ActivationofratliverPPARalphahasbeenshowntosuppresshepatocyteapoptosis.PPARdelta,likeseveralothernuclearhormonereceptors,heterodimerizeswithretinoicXreceptor(RXR)alphatoformatranscriptionallycompetentcomplex.||Applications:|SuitableforuseinELISA,GelShift,Immunohistochemistry,WesternBlot,Neutralization.Otherapplicationsnottested.||RecommendedDilution:|ThispeptidemaybeusedforneutralizationandcontrolexperimentswiththepolyclonalantibodythatreactswiththisproductandPPARdelta,P5505-04.Usingasolutionwithequalweightsperunitvolumeofpeptideandcorrespondingantibodywillyieldasolutionwithalargemolarexcessofpeptidethatisabletocompetitivelybindtheantibody.|Optimaldilutionstobedeterminedbytheresearcher.||StorageandStABIlity:|Lyophilizedpowdermaybestoredat4°Cforshort-termonly.Stablefor12monthsat-20°C.Reconstitutetonominalvolume(seereconstitutioninstructionsforpeptides)andstoreat-20°C.Formaximumrecoveryofproduct,centrifugetheoriginalvialpriortoremovingthecap.Furtherdilutionscanbemadeinassaybuffer.|||

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