14-3-3 varsigma/Stratifin was first identified as an epithelial cell antigen (HME-1) exclusively expressed in epithelia. However, the functional role of varsigma in cell proliferation and apoptosis would suggest that this protein could be relevant to the regulation of growth and differentiation of multiple cell types. Recent evidence demonstrates that varsigma acts as a tumor suppressor gene that is inactivated by methylation of its 5’ CpG islands in epithelial tumor cells. In normal epithelia, varsigma is commonly unmethylated.||Recombinant protein corresponding to aa1-248 of human Stratifin expressed in E. coli with a N-terminus His-Tag (NP_006133.1).||Applications: |Suitable for use in ELISA and Western Blot. Other applications have not been tested.||Quality Control: |SDS-PAGE||Storage and Stability: |For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months. ||Important Note: This recombinant enzyme has NOT been tested with regard to biological activity.

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