TheendothelialProgenitorcell(EPC)isaprimitivecelltypeintheendotheliallineage.Theyarebonemarroworiginatedcellswithpropertiessimilartothoseofembryonicangioblasts.Theseprogenitorcellsmigrateintothebloodstreamandarecapableofdifferentiatingintoavarietyofmaturevascularendothelialcelltypes.EPCplayanimportantroleinbothangiogenesisandvasculogenesis.RecentevidencesuggeststheinvolvementofEPCintumorgrowthandmetastasis.ChangeinEPCnumberhasbeenassociatedwithlymphoma,multiplemyeloma,Lewislungtumor,andhepatocellularcarcinoma(HCC).AlterationinEPCnumberandfunctionhasalsobeenobservedinpathogenesisofavarietyofdiseasesincludingcoronaryarterydisease(CAD),ischemia,pulmonaryhypertension,cerebralvasculardisease,acutemyocardialinfarction,diabetesmellitus,arthritis,andwoundhealing.Inaddition,EPChaveimpactonagingandsmoking-relateddiseases,suggestingpotentialusesofEPCintheseareas.||SpecificationandCharacterizationofEPC:|Humanendothelialprogenitoroutgrowthcells(hEPOC)areisolatedfromcordbloodandfurtherculturedinvitro.OurhEPOCproductisdeliveredatthe4thpassage,eitherascryopreservedorproliferatingcells.ThiscellisconsideredaslatestageEPCbecauseitisCD133-.Eachcryovialcontains>5x10e5cellsin1mlfreezingmedium.OurhEPOChavethecobblestonemorphologycommontoendothelialcells.Theyarecharacterizedbyantigenexpression(CD146,KDR,CD34),vonWillebrandFactorimmunostaining,LDLuptakeandlectinbinding,tubeformationandmigrationassays.HumandonorsarenegativeforHIV-1,HBVorHCV.||Sterility:|Negativefor:MycoplasmamHIV-1,HepatitisBandHepatitisC||CountryofOrigin:|U.S.A.||StorageandStABIlity:|Uponreceiving,immediatelytransfercellsfromdryicetoliquidnitrogenandkeepthecellsinliquidnitrogenuntilcellcultureisneeded.Stableforoneyearfromthedateofpurchaseifappropriatemediaandreagentsareused,andtherecommendedprotocolsforstorageandusearefollowed.

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