Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6).||Physical Appearance:|Colorless frozen solution||Solubility:|>2mg/ml and <5mg/ml||Buffer Composition:|0.05M sodium phosphate; 0.1M sodium chloride; 1mM EDTA; pH 6.6||Purity:|>98% pure by SDS PAGE 95 (+/-) 5% active by uPA titration.||Absorbance (280nm): 3.6 E0.1% = 1.0|Concentration = 3.6mg/ml|Active Concentration = 3.4mg/ml||Kinetic Data:|Second order rate constants for inhibition of:|UPA = 6.3 X 106 M^-1s^-1|tPA = 5.7 X 106 M^-1s^-1||Storage and Stability:|Store frozen at -70°C – stability >1 year.

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