A cell-permeable 2'-benzyloxy griseofulvin derivative that displays enhanced mammalian cancer-selective toxicity (IC50 ≤2, ≤4, ≤12, and ≥30uM against panels of leukemia, myeloma, solid tumors, and non-malignant cell lines, respectively), but little antifungal activity, by activating spindle-assembly-checkpoint without affecting microtubule kinetochore attachment. Cancer cells are reported to undergo multipolar (MP) mitosis with normal or supernumerary centrosomes in the presence of GF-15, resulting in subsequent apoptotic cell death. Shown to retard HT29 colon cancer & OPM2 myeloma tumor expansion in mice (20mg/kg/day i.p.) in vivo. GF-15 half-life is expected to be least 48h in cultures.||Synonyms: |Supernumerary Centrosomes Clustering Inhibitor, 2ʹ-Benzyloxy-2ʹ-demethoxygriseofulvin, (2S,6ʹR)-(7-Chloro-4,6-dimethoxy-benzofuran-3-on)-2-spiro-1ʹ-(2ʹ-benzyloxy-6ʹ-methylcyclohex-2ʹ-en-4ʹ-one), (2S,5ʹR)-3ʹ-benzyloxy-7-chloro-4,6-dimethoxy-5ʹ-methyl-spiro(benzofuran-2,4ʹ-cyclohex-2-ene)-1ʹ,3-dione, (1ʹS,6ʹR)-2ʹ-(benzyloxy)-7-chloro-4,6-dimethoxy-6ʹ-methyl-3H-spiro(benzofuran-2,1ʹ-cyclohex[2]ene)-3,4ʹ-dione||Solubility:|DMSO||Molar Mass:|428.9||Purity: |≥98% (HPLC)||Form: |Supplied as a white solid.||Storage and Stability:|May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

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