A cell-permeable, non-toxic aminopyrazolocarbonitrile compound that acts as a potent, selective, reversible and cAMP-independent activator of CFTR-dependent Cl- channel in airway epithelial cells (EC50 = 1.6uM in CFTR-expressing Fisher rat thyroid cells). Also shown to activate deltaF508-CFTR in primary CF-HBE cell cultures (EC50 = 3.5uM). Reported to directly bind to the same site as CFTRinh-172. Does neither elevate intracellular cAMP levels nor appear to have any requirement for cAMP agonist, such as forskolin. Shown to additively potentiate the G551D-CFTR Cl- current activated by forskolin with CFTR potentiator, VX-770. Exerts no effect on either Ca2+-activated Cl- channel (TMEM16A) or intracellular Ca2+ levels.||Synonyms: |Cystic Fibrosis Transmembrane Conductance Regulator Activator, Cact-A1, 5-((Z)-2-(2-(Allyloxy)phenyl)-1-cyanovinyl)-3-amino-1H-pyrazole-4-carbonitrile, (Z)-3-(2-(2-(Allyloxy)phenyl)-1-cyanovinyl)-5-amino-1H-pyrazole-4-carbonitrile||Molecular Formula:|C₁₆H₁₃N₅O||Solubility:|DMSO (100mg/ml)||Primary Target:|CFTR||Purity: |≥98% (HPLC)||Appearance:|Supplied as a light yellow powder.||Storage and Stability:|May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.||Important Note: |This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. ||Toxicity and Hazards: |All products should be handled by qualified personnel only, trained in laboratory procedures.

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