Mycoplasma pneumoniae (M. pneumoniae) is small atypical bacterium of the Mollicute class, and a member of the family Mycoplasmataceae. M. pneumonia was first isolated by Eaton et al in 1944 and is now recognized as a major cause of respiratory tract infection in humans. In order to infect host cells Mycoplasma pneumonia adheres to ciliated epithelium in the respiratory tract, which requires the interaction of several proteins including P1, P30, P116. P1 protein is a major integral surface molecule located at the tip of Mycoplasma pneumonia. It is an immunogen and one of the major adhesins that plays a key role in cytoadherence, motility and virulence (Chourasia BK). Mycoplasma pneumonia is geographically widespread, causing respiratory disease in children and adults, and is one of the causative agents of community acquired pneumonia. Transmission of Mycoplasma pneumonia from human to human is predominantly through close contact with airborne respiratory droplets from an infected individual. Mycoplasma pneumonia is sensitive to desiccation and therefore close proximity to an infected individual is necessary for successful transmission (CDC). Mycoplasma pneumonia is an extracellular pathogen which lacks a cell wall and has the capability of reproducing by itself. It infects respiratory epithelium in the upper and lower respiratory tract resulting in the gradual development of disease symptoms, which typically occurs over a period of 1- 4 weeks. The clinical symptoms associated with Mycoplasma pneumonia infection are diverse, but the disease is characterized by the onset of fever, headache, general malaise, pharyngitis, tracheobronchitis and a persistent cough that increases in severity. In some cases, infection can result in severe respiratory disease and clinical complications affecting extrapulmonary sites can also occur (Waites KB). Mycoplasma pneumonia infection is self-limiting in most cases but may persist for several months, even after treatment.Diagnosis of Mycoplasma pneumonia infection is currently performed using serological or molecular detection methods. However, current methods of detection are time consuming, and lack the sensitivity, and improved assays are needed for rapid point-of-care diagnosis of the disease (CDC).||Applications: |Suitable for use in Immunofluorescence and ELISA. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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