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当前位置: 首页 > 产品中心 > Other_recombinant_protein > Usbio//50ug/G0900-25
商品详细Usbio//50ug/G0900-25
Usbio//50ug/G0900-25
Usbio//50ug/G0900-25
商品编号: G0900-25
品牌: USbiological
市场价: ¥13840.00
美元价: 5882.00
产地: 美国(厂家直采)
公司:
产品分类: 其它重组蛋白
公司分类: Other_recombinant_protein
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
G6b is a t ype I transmembrane glycoprotein in the immunoglobul in superfamily that is encoded within the human class III major histocompatibility complex (1 ­ 3). It is expressed mainly on platelets, and has also been detected on megakaryocytes and the human cell line K562 (2 ­ 5). Crosslinking of G6b inhibits agonist­stimulated platelet aggregation and activation (5). The 241 amino acid (aa) human G6b isotype B (G6b­B) contains a 17 aa signal sequence, a 125 aa extracellular domain with one V­type Ig ­like domain and one N­linked glycosylation site, a 21 aa transmembrane sequence and a 78 aa cytoplasmic sequence with two ITIM inhibitory motifs and a SH3 bindingsite (1, 2). Phosphorylation at Y211 within the first ITIM is required for interaction with SHP adapt or/ tyrosine phosphatase proteins (2, 3). Of several described isoforms, all are identical within aa 22­136, which includes most of the extracellular domain. One contains an alternate signal sequence, while at least two lack a transmembrane sequence and are secreted (2). At least two others, including G6b­A, express alternate C­t ermini that lack the ITIM motifs. Of the known isoforms, G6b­A and G6b­B predominate in platelets. It is possible that G6b­A may be paired with and control inhibition by G6b­B (4). Heparin interacts with the G6b extracellular domain with high­affinity and may contribute to G6b activity or adhesion to extracellular matrix (6).||Source: Chinese Hamster Ovary cell line, CHO-derived Human G6b (Asn18 Gln142), Accession # O95866, IEGRMD, Human IgG1, (Pro100 Lys330).||Predicted Molecular Mass: 40.0kD (monomer) SDS-PAGE under reducing conditions.||Activity: Measured by its binding ability in a functional ELISA. When 1ug/ml of rhG6b/Fc is captured by a goat anti-human IgG Fc coated plate, the concentration of biotinylated heparin that produces 50% of the optimal binding response is found to be approximately 10-40ng/ml.||Endotoxin: ≤1.0 EU per 1 ug of the protein by the LAL method.||Applications:|Suitable for use in ELISA. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|12 months from date of receipt, 20 to 70°C as supplied.|1 month, 2 to 8°C under sterile conditions after reconstitution.| months, 20 to 70°C under sterile conditions after reconstitution.|Avoid repeated freeze thaw cycles.
品牌介绍
usbio的生化试剂,抗体,重组蛋白,细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境,包括基因组研究,生物技术,药物开发和疾病诊断。 恭喜苏州蚂蚁淘获得usbio2020年授权书,成为usbio中国代理,购买usbio,请认准usbio代理-苏州蚂蚁淘!