Cytosolic sulfotransferases are a family of Phase II drug­metabolizing enzymes that catalyze the sulfation of many endogenous and xenobiotic substrates (1­3). They have important roles in the metabolism of many endogenous compounds including steroids, bile acids, thyroid hormones and monoamine neurotransmitters. They are distributed throughout the body and serve to inactivate and increase water­solubility of xenobiotics and therapeutic drugs. They are distinct from Golgi resident sulfotransferases by lacking N­terminal signal­anchor domains and residing only in the cytoplasm. SULT2A1 is primarily expressed in liver and adrenal tissues where it sulfates steroids and bile acids (4­6). It is also called DHEA/bile acid sulfotransferase and plays roles in maintaining cholesterol and bile acid homeostasis by increasing cholesterol catabolism and, at the same time, preventing toxicity from bile acid accumulation.||Recombinant enzyme corresponding to Ser2-Glu285 with a Met and N-terminal 6 His tag of human Sulfotransferase 2A1 expressed in E. coli. Swiss/UniProt Accession: Q06520||N-terminal Sequence Analysis: |Met||Predicted Molecular Mass: |35kD||SDS-PAGE: |36kD, reducing conditions||Activity: |Measured by its ability to transfer sulfate from PAPS to t-­Dehydroandrosterone (DHEA).||Specific Activity:|≥ 10 pmol/min/ug||Endotoxin: |≤1.0 EU per 1ug (LAL)||Applications:|Suitable for use in Western Blot. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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