In normal tissues and in a variety of myeloproliferative disorders, myeloid cells of both neutrophilic and eosinophilic types, at all stages of maturation, exhibit strong cytoplasmic reactivity for MPO. It is readily detected in myeloblasts and immature myeloid cells of acute myelogenous leukemia, progranulocytic leukemia, monomyelocytic leukemia, erythro-leukemia, myeloblastomas, and other hematopoietic disorders. Erythroid precursors, megakaryocytes, lymphoid cells, mast cells, and plasma cells are nonreactive. Cells of monocytic derivation reveal variable reactivity and are typically weakly positive or nonreactive. Cells comprising the infiltrate of a spectrum of lymphoid malignancies, e.q., lymphoblastic lymphoma or leukemia, chronic lymphocytic leukemia, hairy cell leukemia, non-Hodgkin’s lymphomas of T-or B-cell type, and Hodgkin’s disease, are nonreactive, as are the non-neoplastic tissues present in these specimens, except for occasional cells of myeloid derivation. MPO is not observed in the neoplastic cells of a wide variety of epithelial tumors and sarcomas, or in the contiguous non-neoplastic tissues. MPO is useful in differentiating between myeloid and lymphoid leukemias.||Molecular Weight:|145kD; 145kD, Composed of 2 identical subunits of 72.5kD. Each subunit is joined by a single disulfide bridge yielding peptides of 59 and 13.5kD.||E.C. No: |1.11.1.7||Unit Definition:|One unit of MPO will consume 1 micromole of hydrogen peroxide and produce 0.25 micromole of tetraguaiacol per minute at pH 7, 25ºC.||Specific Activity:|≥800units/mg protein||Applications:|Suitable for use in ELISA. Other applications not tested. ||Recommended Dilutions:|Optimal dilutions to be determined by researcher.||Storage and Stability:|May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.||Non-infectious Disease Statement: |Negative or non-reactive at the donor level for HIV 1 and 2 (NAT), HCV (NAT), and HBsAg. However, because no test method can offer complete assurance that infectious agents are absent, this material should be handled at the Biosafety Level 2 (BSL 2) as recommended for any potentially infectious human serum or blood specimen in the CDC/NIH manual "Biosafety in Microbiological and Biomedical Laboratories", 2009.

usbio的生化试剂，抗体，重组蛋白，细胞培养基和分子生物学试剂盒几乎用于所有科学应用和环境，包括基因组研究，生物技术，药物开发和疾病诊断。 恭喜苏州蚂蚁淘获得usbio2020年授权书，成为usbio中国代理，购买usbio,请认准usbio代理-苏州蚂蚁淘！